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Antifungal Agents, II: Synthesis and Antifungal Activities of Aryl‐1H‐pyrrol‐2‐yl‐1H‐imidazol‐1‐yl‐methane Derivatives with Unsaturated Chains

Massa S., Ragno R., Porretta G.C., Mai A., Retico A., Artico M., Simonetti N., Archiv der Pharmazie, 1993


Abstract:

The synthesis and antifungal activities of aryl‐1H‐pyrrol‐2‐yl‐1H‐imidazol‐1‐yl‐methanes having allyl, crotyl, and acrylate chains linked to the N‐pyrrole atom and substituted at phenyl ring by Cl, F, CH3, and NO2 groups are reported. In vitro tests against Candida albicans and Candida spp. showed 2,4‐dichlorophenyl‐1‐allyl‐1H‐pyrrol‐2‐yl‐1H‐imidazol‐1‐yl‐methane to be the most potent derivative with activities comparable to those of ketoconazole and slightly inferior to those of bifonazole and miconazole. Some structure‐activity relationships are discussed. Copyright © 1993 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim


Link to the article:

http://dx.doi.org/10.1002/ardp.19933260909